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Cefpodoxime is an oral, third-generation cephalosporin antibiotic. It is active against most Gram-positive and Gram-negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. Currently, it is only marketed as generic preparations in the USA, according to the FDA Orange Book. It is commonly used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone ) are no longer necessary for continued treatment.
Zoetis markets cefpodoxime proxetil under the trade name Simplicef for veterinary use. The dose range in dogs is 5–10 mg/kg body weight, administered orally, once a day.
Finecure, India markets the products under trade name Cefpo.
Cefpodoxime inhibits cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis in cell walls. It has well established pharmacokinetic profile with absorption of 50%. It is indicated in community acquired pneumonia, uncomplicated skin and skin structure infections, and uncomplicated urinary tract infections.
Structural formula of cefpodoxime proxetil
1 Spectrum of bacterial susceptibility and resistance
2 Brand Name
4 External links
Spectrum of bacterial susceptibility and resistance
Cefpodoxime has been used to fight pathogenic bacteria responsible for causing gonorrhoea, tonsillitis, pneumonia, and bronchitis. Representative pathogenic genera include Streptococcus, Haemophilus, and Neisseria. The following represents MIC susceptibility data for a few medically significant microorganisms.
Haemophilus influenzae : ≤0.03 – 1 μg/ml
Neisseria gonorrhoeae : 0.004 – 0.06 μg/ml
Streptococcus pyogenes : ≤0.004 – 2 μg/ml
Brand Name: Toraxim (Delta Pharma Ltd. Bangladesh), Trucef (by Renata Limited, Bangladesh).
Marketed Also As : Orelox By SanoFi-Aventis Pharma
MAPDOX-CV Cefpodoxime and Clavulanic acid combination
MONOTAX O (Cefpodoxime)/ MONOTAX CV (Cefpodoxime and Clavulanic acid combination)- Zydus Healthcare Ltd.
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