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Rizatriptan (trade name Maxalt ) is a 5-HT 1 receptor agonist of the triptan class of drugs developed by Merck & Co. for the treatment of migraine headaches. It is available in strengths of 5 and 10 mg as tablets and orally disintegrating tablets (Maxalt-MLT).
Maxalt obtained approval by the United States Food and Drug Administration (FDA) on June 29, 1998. It is a second-generation triptan.
Rizatriptan is available only by prescription in Australia, Finland, the United States, Canada and New Zealand. Similarly, it is classed as a POM (Prescription Only Medicine) in the United Kingdom, Italy (as Rizaliv ), France, Israel (as Rizalt ), The Netherlands, Croatia and Spain (as Maxalt ). It is classified as OTC (over-the-counter) in Brazil (also as Maxalt ).
Contents
1 Indications
2 Contraindications
3 Drug Interactions
4 Adverse effects
5 Mechanism of action
6 References
7 External links
Indications
Rizatriptan is FDA-approved to treat acute migraine attacks with or without aura. It does not prevent future migraine attacks. Rizatriptan is also used off-label to treat cluster headaches.
Contraindications
coronary artery disease
use of monoamine oxidase inhibitors
Drug Interactions
Monoamine oxidase inhibitors
Propranolol
Adverse effects
Severe:
serotonin syndrome when used with MAOIs
coronary artery vasospasm
transient myocardial ischemia           
myocardial infarction
ventricular tachycardia
ventricular fibrillation
hypertensive crisis
Atypical sensations:
paresthesia
Cardiovascular :
palpitations
syncope
hypertension
hypotension
Ear, nose, and throat:
tinnitus
sinusitis
allergic rhinitis
upper respiratory tract inflammation
Gastrointestinal :
diarrhea
Muscular:
myalgia
Neurological:
phonophobia
photophobia
Respiratory:
dyspnea
Skin:
sweating
Miscellaneous:
hypersensitivity
Mechanism of action
Main article: Serotonin receptor agonist
Rizatriptan acts as an agonist at serotonin 5-HT 1B and 5-HT 1D receptors.

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