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Additional information about the drug Amiloride

Amiloride is a prescription medication used to treat high blood pressure and fluid retention caused by congestive heart failure. This medication belongs to a group of drugs called diuretics (“water pills”). Specifically, it is a “potassium-sparing” diuretic which means that it works by helping the body get rid of excess fluid by increasing the amount of salt and water the kidneys remove from the blood, while still keeping potassium in the body.
This medication comes in tablet form and is usually taken once daily or every other day. Take amiloride with food.
Common side effects include headache, nausea, and diarrhea. Amiloride may cause dizziness. Do not drive or operate heavy machinery until you know how it affects you.
Amiloride is prescription medication used to treat high blood pressure and fluid retention caused by congestive heart failure.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Amiloride may be found in some form under the following brand names:
Amiloride; Hydrochlorothiazide, HCTZ: (Moderate) Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the natriuretic effect of diuretics in some patients.

  • The increased voltage and amiloride efficacy in cystic fibrosis reflect absorption of sodium ions across an epithelium that is relatively impermeable to chloride ions.
  • Potassium-sparing diuretics such as amiloride may be added to prevent hypokalemia, but loop diuretics should be avoided.
  • As discussed in C-11 Hydroxylase Deficiency, blood pressure management also is important and involves variable combinations of potassium-sparing diuretics, such as amiloride and triamterene; antialdosterone agents, such as spironolactone; and nondihydropyridine (eg, verapamil) and dihydropyridine (eg, nifedipine) calcium channel blockers.
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