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Additional information about the drug Levofloxacin


Levaquin is the brand name for levofloxacin, a prescription antibiotic drug used to treat a variety of bacterial infections, such as: Pneumonia Acute bacterial sinusitis Chronic bronchitis worsened by bacterial infections Skin infections Chronic prostate gland infection (prostatitis) Urinary tract infection (UTI) Acute kidney infection Inhalational anthrax, or anthrax contracted by breathing in anthrax spores Pneumonic and septicemic plague (Levaquin is also used to prevent contracting plague ) Levaquin belongs to a class of antibacterial agents called fluoroquinolones, which kill bacteria by inhibiting the activity of certain enzymes bacteria require to replicate, transcribe, repair, and recombine DNA.
Doctors may also prescribe Levaquin “off-label” to treat or prevent other bacterial infections, including tuberculosis (TB), Salmonella food poisoning, Shigella food poisoning, Campylobacter infections, and disseminated Mycobacterium avium complex disease, especially for people with a weakened immune system from HIV or other conditions.
Levaquin was first approved by the Food and Drug Administration (FDA) in 1996, and is produced by Janssen Pharmaceuticals, Inc, a subsidiary of Johnson & Johnson.
Levaquin and Tendon Issues In 2008, the FDA required all fluoroquinolone manufacturers to include a black-box warning that the drug class can increase a person’s risk of tendonitis (tendon inflammation) and tendon rupture, a decision that came too late for a lot of people taking Levaquin, resulting in numerous lawsuits.
Plaintiffs charge that Johnson & Johnson should have strengthened their warnings about the potential tendon issues associated with Levaquin before the FDA issued its decree, and also that the company downplayed the drug’s risks to boost sales.
In 2010, Johnson & Johnson lost a court case against 87-year-old John Schedin, and had to pay nearly $2 million to Schedin for the damage he received to his Achilles tendon after taking Levaquin.
The company subsequently won several other court cases, in which plaintiffs failed to show the drug caused their tendon issues.
To date, however, thousands more cases have reached settlements out of court.
The risk of tendonitis and tendon ruptures is greater for people over 60 years old, people taking corticosteroid drugs, and people with kidney, heart, or lung transplants.
Physical activity or exercise, kidney failure, and having previous tendon problems, such as rheumatoid arthritis, can also increase your risk of tendon issues while taking Levaquin.
Levaquin Warnings You should not take Levaquin if you have a known sensitivity or allergy to levofloxacin and other quinolones (the family of antibiotics that encompasses fluoroquinolones).
You should also avoid the drug if you have the neuromuscular disease myasthenia gravis, as the drug could worsen your muscle weakness.
Some people experience other serious and sometimes life-threatening reactions from taking Levaquin, such as: Dangerous skin disorders, including toxic epidermal necrolysis and Stevens- Johnson Syndrome Blood vessel inflammation, joint pain, and muscle pain Allergic pneumonitis, an inflammation of the walls of the lung’s air sacs Interstitial nephritis (a kidney disorder) and kidney failure Hepatitis (liver inflammation), jaundice (yellowing of the skin and eyes), liver cell death, and liver failure Blood-related issues, including deficiencies in red blood cells or white blood cells Pregnancy and Levaquin It’s unknown if Levaquin can harm a developing fetus because no adequate and well-controlled studies have been carried out in pregnant women.
However, the drug’s antimicrobial benefits to the mother may outweigh the potential risks to her unborn child.
Levofloxacin is presumed to be present in breast milk, and the drug has the potential to cause serious side effects in infants.
Breastfeeding mothers taking Levaquin should either discontinue the drug or stop breastfeeding.
BasicDescription Back to Top Levaquin Side Effects Common Side Effects of Levaquin The most common side effects of Levaquin are: Nausea Headache Diarrhea Insomnia Constipation Dizziness Other common side effects include yeast infections, vaginitis, severe itching, chest pain, and swelling from water buildup (edema).
Severe Side Effects of Levaquin Though rare, Levaquin can result in numerous serious side effects that may require medical attention, including: Central nervous system effects, including seizers, hallucinations, nightmares, depression, confusion, paranoia, suicidal thoughts, and tremors Gastrointestinal infections and disorders Potentially irreversible peripheral neuropathy (damage to the nerves outside the brain and spinal cord) Serious heart rhythm changes Joint problems Changes in blood sugar Sensitivity to sunlight Severe diarrhea from the difficult-to-treat bacteria Clostridium difficile Additionally, children taking Levaquin may develop musculoskeletal disorders, such as arthritis and gait abnormalities.
Back to Top Levaquin Interactions Levaquin may interact with: Antacids, multivitamins, and supplements containing magnesium, aluminum, iron, or zinc Sucralfate (Carafate) Didanosine (Videx) Warfarin (Coumadin, Jantoven) Antidiabetic medicine Non-steroidal anti-inflammatory drugs, including aspirin and ibuprofen Theophylline (Theo-24, Theolair) Make sure to tell your doctor about any medications, drugs, and supplements you take, especially steroid medications, anti-psychotic drugs, tricyclic antidepressants, diuretics, and heart-rate medications.
Levaquin and Other Interactions Levaquin may produce a false-positive urine test for opiates.
You should tell your doctor or other healthcare professional that you’re taking Levaquin when submitting a urine sample.
Back to Top Levaquin Dosage Levaquin comes in the various forms: Film coated oral tablets of 250 milligrams (mg), 500 mg, and 750 mg Oral solutions of 25 mg per milliliter (mL), which should be taken 1 hour before or 2 hours after eating Premixed, single-use injection in flexible containers, containing a solution equivalent to 250 mg, 500 mg, or 750 mg of levofloxacin Single-use injection vials containing concentrated levofloxacin solution equivalent to 500 mg or 750 mg, which need to be further diluted with the appropriate solution Only take Levaquin as advised by your doctor.
Dosage and length of treatment differs depending on the type of infection that needs to be treated; adults with kidney problems, as well as children, must follow an adjusted treatment schedule.
Levaquin Overdose According to animal studies, Levaquin is toxic in high doses, causing a number of muscular and nervous system symptoms, such as tremors, convulsions, and loss of control of bodily movements.
Call your local poison control center or visit the nearest emergency hospital room if you’ve overdosed on Levaquin to have your stomach emptied.
Call 9-1-1 if you think someone has overdosed and has collapsed or isn’t breathing.
Missed Dose of Levaquin Take the missed dose as soon as you remember it, unless it’s almost time for next dose.
Never double your dose to make up for a missed dose of Levaquin.
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