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Pseudo-dermatomyositis induced by long-term hydroxyurea therapy: report of two cases.

  • Prospective studies in young males with pretreatment and posttreatment sperm analyses will be necessary to answer this question definitively. Because hydroxyurea reduces intracellular deoxynucleoside triphosphate pools, 32, 33 it affects not only DNA synthesis required for cell division but also DNA repair.
  • Measures to prevent such renal lesions include angiotensin converting enzyme inhibitors and hydroxyurea, which are believed to provide the greatest benefits in the control of sickle cell nephropathy.
  • Anti-inflammatory therapy should be maintained at the initial dose until complete control of active inflammation has been achieved, arimidex for sale cheap Patients whose fetal hemoglobin levels increase with the combination therapy of hydroxyurea and L-arginine or Sildenafil may continue to take them.
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  • Numerous reports have supported the use of a number of different blood products and systemic agents, such as pentoxifylline, antithrombin III concentrate, hydroxyurea (with or without erythropoietin), L-carnitine, arginine butyrate, and periodic transfusions.1’5’6’9’12,16,25-27 However, 20% to 30% of patients become alloimmunized after many transfusions.13 In addition, iron overload may occur with repeat transfusions. Pentoxifylline has been effective in vasoocclusive crises associated with sickle cell anemia by decreasing the frequency of the crises, decreasing occurrence of acute chest syndrome, decreasing the need for transfusions, and increasing the level of fetal hemoglobin.29 Frost and Treadwell25 reported 1 case of sickle cell ulcers treated successfully with pentoxifylline.
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