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Additional information about the drug Paxil Cr


Paxil is the brand name for the antidepressant paroxetine.
Though doctors prescribe Paxil to treat depression, it’s also used to treat anxiety disorders including: Panic disorder Social anxiety disorder Generalized anxiety disorder (GAD) Post-traumatic stress disorder (PTSD) Obsessive-compulsive disorder (OCD) Paxil is also approved by Food and Drug Administration (FDA) to help women manage the hot flashes associated with menopause.
Additionally, doctors may prescribe Paxil off-label to treat conditions other than those for which it has been approved by the FDA.
For example, some doctors prescribe Paxil to treat chronic headaches, and people with diabetes may use the drug to help alleviate tingling in the hands and feet.
Paxil has also been used to treat men who experience premature ejaculation.
A controlled-release form, Paxil CR, can relieve the physical and psychological symptoms some women experience before their menstrual cycle begins each month.
Paxil belongs to a class of antidepressant medications called selective serotonin-reuptake inhibitors (SSRIs).
SSRIs work by boosting levels of serotonin, a neurotransmitter that helps the brain send messages from one nerve cell to another.
Paxil History GlaxoSmithKline makes Paxil, which the FDA first approved in 2001.
Paxil is also available under the brand names Brisdelle and Pexeva.
Generic forms of paroxetine became available in 2003.
GlaxoSmithKline has repeatedly come under fire for its marketing of Paxil and other antidepressants, including accusations that the company misreported data from clinical trials, which showed that Paxil might be unsafe for teenagers and young adults.
In 2012, GlaxoSmithKline agreed to pay a $3 billion fine to U.S.
federal prosecutors, in part for its antidepressant marketing practices.
A study published in the medical journal BMJ in 2015 reanalyzed data from 2001 and found that Paxil was ineffective at treating depression in adolescents.
Additionally, the study found that use of the drug among adolescents was associated with significant harm, including thoughts of suicide and suicide attempts.
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  • First-trimester use of paroxetine and congenital heart defects: a population-based case-control study.
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  • Patients who participated in group therapy and adhered to the medication were more likely to remain abstinent. 203 Research also suggests that this medication may be more effective than bupropion. 200 For example, a meta-analysis found that a combination of varenicline and NRT (especially, providing a nicotine patch prior to cessation) was more effective than varenicline alone. 204 Similarly, adding bupropion to NRT also improved cessation rates. 200 For smokers who could not cut down significantly by using the NRT patch, combining extended-release bupropion and varenicline was more effective than placebo, particularly for men and those who were severely nicotine dependent. 140 A few small studies suggest that nortriptyline is equally effective as NRT. 168,200 Although nortriptyline may have side effects in some patients, the small studies for its use in smoking cessation have not reported any. 200 Researchers have not observed any impact of selective serotonin reuptake inhibitors (SSRIs) (e.g., fluoxetine, paroxetine, and sertraline) on smoking, either alone or in combination with NRT. 200 The field of pharmacogenetics examines how genes influence therapeutic response to medications, providing critical information to help tailor pharmacotherapies to the individual for maximum benefit.
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