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Additional information about the drug Theo-24 Sr

Theo-24 Sr is the generic name for the prescription drugs Uniphyl (in Canada) and Theo-24.
It’s used to treat airflow obstruction symptoms such as wheezing, shortness of breath, and chest tightness related to asthma and lung diseases, including emphysema and chronic bronchitis.
Theo-24 Sr is in a class of drugs called bronchodilators, which relax your bronchial smooth muscles, widening air passageways in your respiratory tract (the bronchi and bronchioles).
This process allows more air to get into your lungs, and lets you exhale more effectively.
The drug also suppresses your airway responses to stimuli, helping prevent some asthma attacks.
Theo-24 Sr may be prescribed off-label to treat sleep apnea or asthma attacks that aren’t responding to other treatments.
It’s also sometimes used for breathing problems in premature infants.
The Food and Drug Administration first approved Uniphyl theophylline (produced by Purdue Pharma) in 1982, and Theo-24 (UCB Inc.) in 1983.
Theo-24 Sr Warnings You should not use theophylline if you’re hypersensitive to the drug or its components.
Theo-24 Sr can also worsen some conditions, so you shouldn’t use it if you have: Ulcers Seizure disorders Some forms of cardiac arrhythmias (abnormal heart rate) Under certain conditions, the drug can remain in your body longer than normal and build up to unsafe levels, resulting in fatal toxic reactions.
In these cases, you should not take theophylline unless the benefits clearly outweigh the risk, and then your doctor will have to carefully decide on your dosage and monitor your blood for levels of the drug.
The conditions that can lead to a deadly toxic reaction include: Being younger than 1 year old, or older than 60 years Congestive heart failure and right-sided heart failure (cor pulmonale) that typically arises from high blood pressure A buildup of fluid in the lungs (acute pulmonary edema) Liver disease, acute hepatitis, or cirrhosis (scarring of the liver) Reduced kidney function Cystic fibrosis A fever of 102 Fahrenheit or more that lasts 24 hours, or a low fever that lasts longer than a day A high- carbohydrate, low-protein diet Thyroid disease A state of physical shutdown called shock Sepsis (blood infection) with multi-organ failure The flu Tobacco and marijuana smoking Stopping smoking Taking or stopping certain drugs while on theophylline You need to be very careful about other drugs you are on or stop taking because of the same potentially fatal toxic reaction.
Pregnancy and Theo-24 Sr Theo-24 Sr is an FDA Pregnancy Category C drug, meaning that a possible risk to developing fetuses cannot be ruled out.
Studies in animals have shown that the drug can cause birth defects, but no adequate and well-controlled studies have been conducted in pregnant women.
Theo-24 Sr should only be used during pregnancy if the potential benefits to the mother outweigh the risks to her unborn child.
Theo-24 Sr is excreted in breast milk, potentially causing irritability and other signs of mild toxicity in breastfeeding infants.
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  • The conversion of theophylline anhydrate to monohydrate, combined with reduced exposure of the drug to the flowing dissolution medium resulted in decreased dissolution rates.
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