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CYP2C9 is a protein in your body that is involved in the elimination of celecoxib and other drugs from your body. Some patients have less of this protein in their bodies, affecting how much of the drug gets eliminated. Levels of CYP2C9 can vary greatly between individuals, and those having less of this protein are known as “poor metabolizers.”
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COX-2 inhibitors: Celecoxib( Celebrex), Valdecoxib (Bextra) Rofecoxib (Vioxx) Less risk of gastrointestinal bleeding, but increased cardiovascular risk, which is why several were removed from the market.
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