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Indocin (Indocin) is a prescription drug used to treat moderate to severe pain, swelling, and stiffness from arthritis.
Indocin belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs).
These drugs treat swelling, pain, and fever by blocking the production of substances in the body called prostaglandins, which regulate inflammation and other bodily processes.
Indocin is approved to treat: Moderate to severe osteoarthritis (wear-and-tear arthritis) Rheumatoid arthritis (inflammatory arthritis) Ankylosing spondylitis (inflammatory arthritis of the spine) Doctors may also use indomethacin to treat bursitis (shoulder joint inflammation), gout, or gouty arthritis, (a form of arthritis caused by crystals of uric acid building up inside joints), and inflammation of tendons (tissue that attaches muscles to bones).
The Food and Drug administration (FDA) approved indomethacin in 1965 for the drug company Iceutica Operations under the brand name Indocin.
Today, several drug manufacturers make generic versions of the drug.
It’s also sold under other brand names, including Indo-Lemmon and Tivorbex.
Indocin Warnings Indocin and other NSAIDs can cause heart attack and stroke.
These can occur without warning and can be fatal.
This risk may increase if you take indomethacin for a prolonged period of time.
You also may be at higher risk if you have a history of heart disease or high blood pressure.
Taking indomethacin may trigger high blood pressure or make it worse, and high blood pressure is a risk factor for stroke and heart attack.
Indocin and other NSAIDs may cause ulcers, perforations, and sudden bleeding in your stomach or intestine (known as gastrointestinal, or GI, bleeding).
This can occur at any time during treatment.
You may be at higher risk for GI bleeding if you are elderly, drink a lot of alcohol, smoke, are in poor health, or take any blood-thinning medication.
You may also be at higher risk if you have a history of ulcers or GI bleeding.
To assess the protective effect of metronidazole on mitochondrial uncoupling induced by indomethacin and also on the increased intestinal permeability and macroscopic damage.
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