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Chloroquine is a prescription medication used to prevent and treat malaria. It is also used to treat amebiasis (an infection caused by the parasite Entamoeba histolytica ). This medication belongs to a group of drugs called antimalarials and amebicides. The exact way it works to kill parasites is unknown.
Chloroquine comes in tablet form. Take this medication with food to minimize stomach upset. Chloroquine is taken once or twice a day. If used for the prevention of malaria, it is taken once a week beginning 2 weeks prior to traveling to an area where malaria is common.
Common side effects include headache, loss of appetite, diarrhea, and upset stomach.
G6PD is an enzyme in your body that is responsible for helping red blood cells to work properly. Some patients are born with less of this enzyme in their bodies, leading to the destruction of red blood cells. Chloroquine can also lead to the destruction of red blood cells. When chloroquine is used in patients with G6PD deficiency, they have a higher chance of experiencing hemolytic anemia (a condition in which the body does not have enough red blood cells to deliver oxygen to your tissues).
G6PD testing may be done to determine whether you are at a higher risk of experiencing hemolytic anemia if you are to be treated with chloroquine.
If you need the medication chloroquine and you have a deficiency of G6PD, your doctor will monitor you carefully.
Edwards MH, Pierangeli S, Liu X, Barker JH, Anderson G, Harris EN (1997) Hydroxychloroquine reverses thrombogenic properties of antiphospholipid antibodies in mice.
Subtle change on the 7-substituent of the chloroquine aromatic structure can also greatly affect the ability of the CQ analogues to enhance transgene expression. Hydroxychloroquine generally is given to adults in doses of 200 mg or 400 mg per day. Chilblain 115. Childbirth 116. Chloroquine — Teratogenic Agent 117.
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