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Endep is a prescription drug that’s used to treat depression.
It’s sometimes known by its former brand name, Elavil, but its manufacturer, AstraZeneca, stopped making it.
Endep is only available as a generic drug in the United States.
Besides depression, amitriptyline can be used “off-label” to treat post-herpetic neuralgia (a condition that occurs after having shingles ), attention deficit hyperactivity disorder (ADHD), and certain eating disorders.
It may also be used to prevent symptoms of migraines.
Endep is in an older class of drugs called tricyclic antidepressants (TCAs), which include some of the earliest medications designed to treat depression.
Other drugs in this class are desipramine (Norpramin), nortriptyline (Pamelor, Aventyl), and imipramine (Tofranil).
These antidepressants work by stopping the brain’s nerve cells from absorbing the neurotransmitters epinephrine and serotonin.
Tricyclic antidepressants are more likely to cause serious side effects than today’s newer antidepressants, such as Prozac and other selective serotonin reuptake inhibitors (SSRIs), so doctors don’t prescribe amitriptyline as often as they once did.
Endep was originally approved by the Food and Drug Administration (FDA) in 1983.
Endep Warnings The FDA requires amitriptyline to carry a black-box warning because of the risk of suicide.
In short-term studies, a small number of children, teen-agers and young adults (up to 24 years old) who took antidepressants such as amitriptyline became suicidal shortly after starting treatment.
You may have suicidal thoughts while taking an antidepressant, especially if you are younger than 24 years old.
Your family members or other caregivers should watch for changes in your mood or other symptoms.
You, a family member, or caregiver should tell your doctor right away if you experience any of the following symptoms while taking amitriptyline (especially during the first weeks of treatment or any time you change your dose): Thoughts of harming or killing yourself Worsening depression Extreme worry or other new feelings of anxiousness Agitation Panic attacks Difficulty falling asleep or staying asleep Aggressive behavior Irritability Unusual restlessness Unusual mood or behavior changes Unusual excitement or hyperactivity Agitation, hostility, or aggressiveness Unusually impulsive behavior Children under age 18 should not take amitriptyline, but in rare cases, a doctor may decide the benefits outweigh the risks.
Before having any type of surgery, you should tell your surgeon that you are taking amitriptyline.
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