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Piroxicam / p aɪ ˈ r ɒ k s ɪ ˌ k æ m / ( INN, BAN, USAN, AAN ; in some countries it is spelled piroksikam or piroxikam) is a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class used to relieve the symptoms of painful inflammatory conditions like arthritis. Piroxicam is one of the few NSAIDs that can be given parenteral routes.
It was originally brought to market by Pfizer under the tradename Feldene in 1980, became generic in 1992,
1 Medical uses
2 Adverse effects
3 Mechanism of action
4 Chemical properties
6 See also
It used in the treatment of rheumatoid and osteoarthritis, primary dysmenorrhoea, postoperative pain; and act as an analgesic, especially where there is an inflammatory component.
See also: Nonsteroidal anti-inflammatory drug
As with other NSAIDs the principal side effects include: digestive complaints like nausea, discomfort, diarrhoea and bleeds or ulceration of the stomach, as well as headache, dizziness, nervousness, depression, drowsiness, insomnia, vertigo, hearing disturbances (such as tinnitus ), high blood pressure, oedema, light sensitivity, skin reactions (including, albeit rarely, Stevens-Johnson syndrome and toxic epidermal necrolysis ) and rarely, kidney failure, pancreatitis, liver damage, visual disturbances, pulmonary eosinophilia and alveolitis.
Mechanism of action
See also: Nonsteroidal anti-inflammatory drug
Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor possessing both analgesic and antipyretic properties.
Piroxicam exists as enol tautomer in organic solvents and as zwitterionic form in water.
The project that produced piroxicam began in 1962 at Pfizer ; the first clinical trial results were reported in 1977, and the product launched in 1980 under the brand name “Feldene”.
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