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The treatment regimen of cyclophosphamide, Oncovin (vincristine), prednisone, bleomycin, Adriamycin (doxorubicin), and Matulane (procarbazine) (COP-BLAM) and ifosfamide, mesna uroprotection, methotrexate, and etoposide (IMVP-16) has been used.
Leuprolide essentially causes the ovaries to temporarily stop making eggs—the hope is that the cyclophosphamide will not permanently injure the resting eggs since cyclophosphamide primarily damages cells that are actively multiplying in the body. Many researchers have tried to solve this problem by injecting no DC and cyclophosphamide to adult mice in order to ablate B cells with specificity for shared antigens, or by injecting neonatal mice no DC in order to tolerize B cells with specificity for shared antigens. Appel GB, Contreras G, Dooley MA, Ginzler EM, Isenberg D, Jayne D, Li LS, Mysler E, Sanchez-Guerrero J, Solomons N, Wofsy D; Aspreva Lupus Management Study Group: Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis. A few nonrandomized studies demonstrated similar rates of remission induction with intermittent intravenous cyclophosphamide as those using the daily oral drug ( 21 ).
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