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Primidone
Primidone is a prescription medication used to treat seizures in adults and children. Primidone belongs to a group of drugs called anticonvulsants, which work by decreasing abnormal electrical activity in the brain.
This medication comes in tablet form and is taken one to three times a day, with or without food.
Common side effects of primidone include drowsiness, problems with walking or moving, and dizziness. Do not drive or operate machinery until you know how primidone will affect you.
Primidone is a prescription medication used alone or with other medicines to treat people with:
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Primidone may be found in some form under the following brand names:
Primidone is part of the drug class:
Primidone may cause other serious side effects including:
The most common side effects of primidone include:
These are not all the possible side effects of primidone. For more information, ask your healthcare provider or pharmacist.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your healthcare provider about all of the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
This is not a complete list of primidone drug interactions. Ask your healthcare provider or pharmacist for more information.
Do not stop taking primidone without first talking to your healthcare provider.
Stopping primidone suddenly can cause serious problems.
Primidone can cause serious side effects, including:
Like other antiepileptic drugs, primidone may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.
Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:
Watch for early symptoms of suicidal thoughts and actions:
Call your healthcare provider between visits as needed, especially if you are worried about symptoms.
Do not stop primidone without first talking to a healthcare provider.
Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.
Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of primidone there are no specific foods that you must exclude from your diet when receiving primidone.
Before you take primidone, tell your healthcare provider if you:
Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Taking primidone with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.
Know the medicines you take. Keep a list of them and show it to your healthcare provider and pharmacist each time you get a new medicine.
Tell your healthcare provider if you are pregnant or planning to become pregnant. Primidone may harm your unborn baby. Tell your healthcare provider right away if you become pregnant while taking primidone. You and your healthcare provider will decide if you should take primidone while you are pregnant.
Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Primidone can pass into breast milk. Talk to your healthcare provider about the best way to feed your baby if you take primidone.
Take primidone exactly as prescribed. Your healthcare provider will tell you how much primidone to take and when to take it.
What to avoid while taking primidone:
Take primidone exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you.
Patients 8 years of age and older who have received no previous treatment may be started on primidone according to the following regimen using either 50 mg or scored 250 mg primidone tablets:
Days 1 to 3: 100 to 125 mg at bedtime. Days 4 to 6: 100 to 125 mg twice daily. Days 7 to 9: 100 to 125 mg three times daily. Day 10 to maintenance: 250 mg three times daily.
For most adults and children 8 years of age and over, the usual maintenance dosage is three to four 250 mg primidone tablets in divided doses (250 mg three or four times daily). If required, an increase to five or six 250 mg tablets daily may be made but daily doses should not exceed 500 mg four times daily.
In patients already receiving other anticonvulsants, primidone should be started at 100 to 125 mg at bedtime and gradually increased to maintenance level as the other drug is gradually decreased.
For children under 8 years of age, the following regimen may be used:
Days 1 to 3: 50 mg at bedtime. Days 4 to 6: 50 mg twice daily. Days 7 to 9: 100 mg twice daily. Day 10 to maintenance: 125 mg three times daily to 250 mg three times daily.
For children under 8 years of age, the usual maintenance dosage is 125 to 250 mg three times daily or, 10 to 25 mg/kg/day in divided doses.
If you take too much primidone, call your healthcare provider or local Poison Control Center right away.
Store primidone at room temperature between 68°F to 77°F (20°C to 25°C) in a tight, light-resistant container.
Keep primidone and all medicines out of the reach of children.

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