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Cyclosporine is the generic name of the prescription eye drop Restasis, used to treat dry eyes caused by an inability to produce enough natural tear fluid.
The drug is also marketed under the brand names Neoral, Sandimmune, and Gengraf to reduce the risk of organ transplant rejection.
Restasis is also used to treat a variety of rare eye conditions, including corneal melt, a serious condition often associated with autoimmune disorders such as psoriasis, rheumatoid arthritis or lupus.
Cyclosporine belongs to a group of drugs known as immunosuppressants, which limit the body’s ability to reject what it perceives to be foreign tissue or organs.
The Food and Drug Administration (FDA) first approved cyclosporine in liquid form under the brand name Sandimmune in 1983.
Novartis manufactures Sandimmune.
Cyclosporine Use in Organ Transplants Neoral, Sandimmune, and Gengraf come in capsules or liquid formulations of cyclosporine to be taken by mouth.
Doctors often prescribe it to help reduce the risk of organ rejection in patients who have received an organ transplant.
Cyclosporine Warnings Restasis has no black-box warnings.
But all forms of cyclosporine taken by mouth have six black-box warnings: You shouldn’t switch between dosage forms or brands of oral cyclosporine, because each formulation delivers a different amount of cyclosporine.
People taking Gengraf are at increased risk of abnormal growth of new cells, which may potentially become cancerous.
An increased risk of skin cancer may occur in people who have psoriasis — especially if you’re taking or have taken methotrexate or other drugs that weaken the immune system.
Even at standard doses, cyclosporine may cause high blood pressure or kidney problems.
Cyclosporine prescribed either for rheumatoid arthritis or to prevent organ transplant rejection requires monitoring.
Oral forms of cyclosporine should only be administered by trained healthcare professionals in an appropriate medical facility.
You shouldn’t use Restasis if you’re allergic to cyclosporine or any other ingredients found in the drug.
Here are a few important reminders about Restasis: Try not to touch the tip of the applicator with your hands, to any part of your eye, or to any other object.
Don’t wear your contact lenses while applying the drops to your eyes.
It’s okay to use artificial tears while using Restasis, but remember to apply Restasis first and wait 15 minutes before using the next eye drops.
Pregnancy and Cyclosporine There is some evidence that cyclosporine may cause harm to a developing fetus.
Your doctor will determine whether the benefit of using the drug is worth the risk to your unborn baby.
Cyclosporine is found in breast milk.
Experts don’t recommend using this medication while breastfeeding.
It’s always a good idea to talk to your doctor about all medications you’re taking if you’re pregnant, might become pregnant, or are breastfeeding.
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BasicDescription Back to Top Cyclosporine Side Effects Common Side Effects Tell your doctor if any of the following side effects become severe or don’t go away: Pain, burning, or discharge from the eye Bloodshot eyes A feeling like something is in your eye Itching and blurry vision Serious Side Effects The main serious side effect of using Restasis is having an allergic reaction to the drug.
Call your doctor immediately if you experience such a reaction.
Back to Top Cyclosporine Interactions Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you’re taking.
In general, Restasis doesn’t really appear to have many drug interactions.
But if you’re taking cyclosporine capsules or solution, you might want to ask your doctor or pharmacist about Restasis before using it.
Cyclosporine and Alcohol Alcohol can cause the eyes to dry out further, defeating the purpose of using Restasis.
So if you can, try to avoid or limit drinking alcohol while using Restasis.
Cyclosporine and Grapefruit Juice You should avoid eating grapefruit and drinking grapefruit juice while using drugs that contain cyclosporine.
Back to Top Cyclosporine Dosage Restasis eye drops come in a strength of 0.05 percent.
For dry eyes, a typical dose is one drop in each eye twice a day.
If you can, try to wait as close to 12 hours as possible between each dose.
Cyclosporine Overdose Generally, overdosing on cyclosporine eye drops shouldn’t be an issue.
But if you suspect an overdose, contact a poison control center or emergency room immediately.
You can get in touch with a poison control center at 800-222-1222.
Missed Dose of Cyclosporine If you miss a dose of cyclosporine, try to take it as soon as you remember.
But skip the missed dose if it’s almost time for your next scheduled dose.
Don’t take extra medicine to make up for a missed dose.
Back to Top Cyclosporine Pictures Cyclosporine Mod 100 mg-IVA, gold,, Cyclosporine Mod 50 mg-IVA, gold,, Cyclosporine 25 mg-APO, brown, capsule, Cyclosporine Mod 25 mg-IVA, gold, oval, Cyclosporine 100 mg-APO, brown, capsule,
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