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Theophylline is the generic name for the prescription drugs Uniphyl (in Canada) and Theo-24.
It’s used to treat airflow obstruction symptoms such as wheezing, shortness of breath, and chest tightness related to asthma and lung diseases, including emphysema and chronic bronchitis.
Theophylline is in a class of drugs called bronchodilators, which relax your bronchial smooth muscles, widening air passageways in your respiratory tract (the bronchi and bronchioles).
This process allows more air to get into your lungs, and lets you exhale more effectively.
The drug also suppresses your airway responses to stimuli, helping prevent some asthma attacks.
Theophylline may be prescribed off-label to treat sleep apnea or asthma attacks that aren’t responding to other treatments.
It’s also sometimes used for breathing problems in premature infants.
The Food and Drug Administration first approved Uniphyl theophylline (produced by Purdue Pharma) in 1982, and Theo-24 (UCB Inc.) in 1983.
Theophylline Warnings You should not use theophylline if you’re hypersensitive to the drug or its components.
Theophylline can also worsen some conditions, so you shouldn’t use it if you have: Ulcers Seizure disorders Some forms of cardiac arrhythmias (abnormal heart rate) Under certain conditions, the drug can remain in your body longer than normal and build up to unsafe levels, resulting in fatal toxic reactions.
In these cases, you should not take theophylline unless the benefits clearly outweigh the risk, and then your doctor will have to carefully decide on your dosage and monitor your blood for levels of the drug.
The conditions that can lead to a deadly toxic reaction include: Being younger than 1 year old, or older than 60 years Congestive heart failure and right-sided heart failure (cor pulmonale) that typically arises from high blood pressure A buildup of fluid in the lungs (acute pulmonary edema) Liver disease, acute hepatitis, or cirrhosis (scarring of the liver) Reduced kidney function Cystic fibrosis A fever of 102 Fahrenheit or more that lasts 24 hours, or a low fever that lasts longer than a day A high- carbohydrate, low-protein diet Thyroid disease A state of physical shutdown called shock Sepsis (blood infection) with multi-organ failure The flu Tobacco and marijuana smoking Stopping smoking Taking or stopping certain drugs while on theophylline You need to be very careful about other drugs you are on or stop taking because of the same potentially fatal toxic reaction.
Pregnancy and Theophylline Theophylline is an FDA Pregnancy Category C drug, meaning that a possible risk to developing fetuses cannot be ruled out.
Studies in animals have shown that the drug can cause birth defects, but no adequate and well-controlled studies have been conducted in pregnant women.
Theophylline should only be used during pregnancy if the potential benefits to the mother outweigh the risks to her unborn child.
Theophylline is excreted in breast milk, potentially causing irritability and other signs of mild toxicity in breastfeeding infants.
It’s not likely to cause serious side effects in infants unless the breastfeeding mother has very high concentrations of the drug in her body.
Nonetheless, if you are breastfeeding your child, you shouldn’t take theophylline unless the potential benefits outweigh the risks, and then only under the guidance of your doctor.
Theophylline for Dogs and Cats The FDA has not approved theophylline for veterinary medicine, but it is commonly prescribed to treat heart failure, asthma, pulmonary edema, bronchitis, and chronic obstructive pulmonary disease in cats and dogs.
As with people, pets are more likely to experience issues with theophylline if they have certain health conditions or are also taking other medications.
Potential side effects include restlessness, upset stomach, frequent urination, and rapid heartbeat.
Always talk to your pet’s veterinarian before giving your dog or cat any prescription drug, including theophylline.
BasicDescription Back to Top Theophylline Side Effects Common Side Effects of Theophylline Although these effects are common, they can be serious and are likely to mean your doctor should change your dosage.
Tell your doctor if you experience any of the following, and if the effect becomes severe, get immediate medical help: Nausea and vomiting Headache Upset stomach Loss of appetite Fast, strong heartbeat Irregular heartbeat ( arrhythmia ): usually there are no symptoms, but it can cause a fluttering feeling, dizziness, shortness of breath, chest pain, heartbeats that feel too fast or slow, or fainting Symptoms similar to how you feel when you’ve had too much coffee, such as trouble falling asleep (insomnia), restlessness, and irritability.
Skin rash Severe Side Effects of Theophylline You need immediate emergency medical treatment if you are experiencing: Seizures Rare Side Effects of Theophylline Tell your doctor right away or get emergency medical help if you experience any of the following more rare side effects: Stomach pain Anxiety Diarrhea Dizziness Tremors Urination issues, including frequent or infrequent urination and hyperuricemia (high levels of uric acid) Allergic reaction Reflux Back to Top Theophylline Interactions Some drugs can affect your body’s ability to process theophylline, potentially causing it to build up to unsafe levels and become toxic.
In addition, theophylline interacts with a wide variety of other drugs, so it’s especially important to tell your doctor about any medications, illegal or recreational drugs, herbal remedies, and supplements you’re taking, even if you are smoking tobacco.
The following drugs are especially important to tell your doctor about before you take theophylline: Adenosine (Adenoscan) Allopurinol (Zyloprim) Aminoglutethimide (Cytadren) Carbamazepine ( Tegretol ) Cimetidine Ciprofloxacin (Cipro) Clarithromycin (Biaxin) Diazepam (Valium) Disulfiram ( Antabuse ) Enoxacin Ephedrine Erythromycin (Ery-tab) Estrogen -containing oral contraceptives Flurazepam (Dalmane) Fluvoxamine ( Luvox ) Halothane (Fluothane) Interferon Isoproterenol (Isuprel) Ketamine (Ketalar) Lithium Lorazepam (Ativan) Methotrexate ( Trexall ) Mexiletine (Mexitil) Midazolam Moricizine Pancuronium (Pavulon) Pentoxifylline (Trenal) Phenobarbital Phenytoin ( Dilantin ) Propafenone (Rythmol) Propranolol ( Inderal ) Rifampin (Rifadin) Ritonavir Roflumilast (Daliresp) St.
John’s wort Sulfinpyrazone (Anturane) Tacrine (Cognex) Thiabendazole (Mintezol) Ticlopidine (Ticlid) Troleandomycin (Tao) Verapamil (Calan) Theophylline and Alcohol Drinking alcohol while taking theophylline may cause the drug to remain in your body for up to 30 percent longer, which can lead to serious toxic effects.
Therefore, you should not drink alcohol when taking theophylline.
Back to Top Theophylline Dosage Your doctor may start you on a low dose of theophylline then gradually increase it while monitoring your symptoms and blood levels for the drug.
Theophylline (Uniphyl and Theo-24) comes as controlled-release tablets, which are generally taken once a day with food or within one to two hours of mealtime.
Theophylline also can be taken multiple times per day in an oral solution form.
Tablets must be swallowed whole.
You must not chew, split, or crush them.
Theophylline Overdose A sudden overdose from taking too much theophylline all at once is rare.
A chronic overdose, however, is not rare, especially if you have been taking a dose that is a little too high for a long time, or if your dose has recently been increased.
An overdose of theophylline may cause slow heart rate, abnormal heart rate, seizures, circulatory system failure, and death.
If you suspect an overdose, you should contact a poison-control center or emergency room immediately.
You can reach a poison-control center at (800) 222-1222.
Missed Dose of Theophylline Missing a dose of theophylline may cause your asthma or bronchitis symptoms to reappear.
If you remember your missed dose within 6 hours of your regular dosing time, take your missed dose immediately.
Take half a dose if you remember the missed dose between 6 and 18 hours after your regular time.
If more than 18 hours have passed since your missed dose, skip it and take your next dose at your regular dosing time.
Never double-up a dose of theophylline.
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