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Clonidine is a prescription medication used to treat high blood pressure, ADHD, and cancer pain. Clonidine belongs to a group of drugs called centrally acting alpha-agonist hypotensive agents, which work by relaxing the blood vessels and decreasing heart rate. It also prevent pain signals from being sent to the brain. The way it works to treat ADHD is not well understood.
This medication comes in tablet, extended-release tablet, and patch forms. The tablet and extended-release tablet is usually taken twice a day, with or without food. Clonidine also comes as a patch that is placed on the skin once every 7 days.
This medication is also available in an injectable form to be given by a healthcare professional.
Common side effects of clonindine include dry mouth, constipation, and sedation. Clonidine can also cause dizziness or drowsiness. Do not drive or operate heavy machinery until you know how this medication will affect you. Alcohol may intensify this side effect.
Clonidine is a prescription medication used to treat high blood pressure, ADHD, and cancer pain.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Clonidine may be found in some form under the following brand names:
Clonidine is part of the drug class:
Common side effects of clonidine tablets and extended-release include:
Common side effects of the clonidine patch include:
Common side effects of clonidine injectable include:
This is not a complete list of clonidine side effects. Ask your doctor or pharmacist for more information.
Serious side effects have been reported with clonidine. See “Drug Precautions” section.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
This is not a complete list of clonidine drug interactions. Ask your doctor or pharmacist for more information.
Serious side effects have been reported with clonidine including:
Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of clonidine, there are no specific foods that you must exclude from your diet when receiving clonidine.
Alcohol may intensify some of the side effects of this medication.
Before taking clonidine, tell your doctor about all of your medical conditions. Especially tell your doctor if you:
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories – A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Clonidine falls into category C. No adequate studies have been done in pregnant women. Animal study results do not always equal that of human response. Clonidine should be used during pregnancy only if clearly needed. It is not known if clonidine will harm your unborn baby.
Tell your doctor if you are breastfeeding or plan to breastfeed.
The active ingredient in clonidine is excreted in human breast milk. The effect of clonidine on the nursing infant is not known.
Take clonidine exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
If you take too much clonidine call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.
If clonidine is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.
The 500 mcg/mL injectable strength product must be diluted prior to use in an appropriate solution.
NOTE: Clonidine injection (epidural clonidine) is not recommended for obstetrical, postpartum, or perioperative pain management. The risk of hemodynamic instability, especially hypotension and bradycardia, from epidural clonidine may be unacceptable in these patients. However, in a rare obstetrical, postpartum or perioperative patient, potential benefits may outweigh the possible risks.

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