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Additional information about the drug Rabeprazole

Aciphex 10mg 20mg – “Rabeprazole, Pariet, Rablet, Rabicip” “Duodenal Ulcers, Gastroesophageal Reflux Disease, GERD, Heartburn, Zollinger-Ellison Syndrome, Helicobacter Pylori”
Rabeprazole is a prescription medication used to treat digestive problems such as heartburn and acid reflux.  Rabeprazole belongs to a group of drugs called proton-pump inhibitors (PPIs). It works by reducing the amount of acid produced in the stomach.
Rabeprazole comes in a delayed release tablet and is usually taken once a day. Swallow rabeprazole tablets whole. Do not chew, crush or split rabeprazole tablets.
Rabeprazole also comes in a sprinkle delayed release capsule and is usually taken once a day.
Common side effects of rabeprazole include headache, sore throat, and constipation.
CYP2C19 is an enzyme in the blood that is responsible for breaking down rabeprazole and other drugs in the body. Some patients have less of this protein in their bodies, affecting how much of the drug gets eliminated. Levels of CYP2C19 can vary greatly between individuals, and those having less of this protein are known as “poor metabolizers.” 
CYP2C19 testing is done to determine whether you are a poor metabolizer. If you are a poor metabolizer, the levels of rabeprazole in your blood can become too high. As a result you may be at an increased risk of having more side effects from rabeprazole. 
Morelli G, Chen H, Rossiter G, Rege B, Lu Y. An open-label, parallel, multiple-dose study comparing the pharmacokinetics and gastric acid suppression of rabeprazole extended-release with esomeprazole 40 mg and rabeprazole delayed-release 20 mg in healthy volunteers.

  • These include Prilosec (omeprazole), Prevacid (lansoprazole) and AcipHex (rabeprazole), taken once or twice a day.
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