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Additional information about the drug Sparfloxacin

Sparfloxacin (spar FLOX a sin), trade names Spacin in Bangladesh, Zagam and Zagam Respipac, is a fluoroquinolone antibiotic used in the treatment of bacterial infections. It has a controversial safety profile. Zagam is no longer available in the United States.
1 Pharmacological properties
2 Medical uses
3 Adverse drug reactions
4 Mechanism of action
5 See also
Development and evaluation of a novel in situ gel of sparfloxacin for sustained ocular drug delivery: in vitro and ex vivo characterization. However, the major problem encountered in these dosage forms is precorneal elimination of the drug, resulting in poor bioavailability and therape.

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  • Hence, grepafloxacin and sparfloxacin should be used with extreme caution, if at all, in patients taking other medications that are known to prolong the QT interval or induce torsades de pointes ( Table 10 ) ( 249 ).
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